분당서울대학교병원에 찾아오시는 길입니다.
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수술중 병리과로 의뢰된 암조직을 급속 냉동하여 진단을 하는, “동결 절편 진단” 은 외과적 수술의 범위를 결정하는데 매우 중요한 병리학적 진단 과정이다. 하지만, 폐는 공기로 가득 차 있으므로, 수술을 통해 체외로 적출되는 순간 공기가 빠져나오면서 장기의 모양이 변하는 특성이 있어서 동결 절편에 적합하지 않다. 최근 CT 등 영상의학의 발달로 조기 폐암의 진단이 늘어나고 있는데, 이러한 조기 폐암은 폐의 구조가 변형되면 진단이 불가능한 특성이 있어서, 의심스러운 병변이 포함된 폐 전체를 절제 할 것인지 혹은 그 주변의 폐만 일부 절제할 것인지 방침을 결정하기 어려운 실정이었다. 본 연구진은 동결 절편 과정에서 폐의 구조가 변형되지 않도록 공기를 머금은 상태와 유사하게 확장되도록 하는 방법을 고안하였고, 이 방법을 통해 동결 절편을 시행한 결과 조기 폐암의 동결 절편 진단율이 100%에 달함을 세계 폐암 학회지에 보고하였다. 이 방법을 통하여, 침윤이 없는 조기 폐암으로 진단된 환자의 경우, 흉부외과에서는 병변 주변의 폐 일부만 절제하는 최소 침습 수술을 시행할 수 있고 폐기능을 더 잘 보존할 수 있게 되었다.
3mm 크기의 조기 폐암병변 |
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최근 폐암에서는 종양 발생에 직접적 원인을 제공하고, 암세포의 성장, 침윤, 진행에 강력한 영향을 미칠 뿐 아니라 기타 세포 성장에 관여하는 다양한 신호전달체계를 교란시키는 암유전자가 발견 되었고 이 암유전자를 표적 치료하였을 때 놀라운 치료 효과를 거둠으로써 진단과 치료원칙의 패러다임이 변화하게 되는 격변의 시기를 맞고 있다. 대표적 예로, 2004년 EGFR 유전자 변이가 있는 폐암 환자에서 특정 타이로신 키나아제 억제제 (tyrosine kinase inhibitors; TKIs, gefitinib or erlotinib)를 사용하였을 때 신속하고도 효과적인 종양 억제효과가 있음이 밝혀졌다. EGFR 변이가 있는 폐암 환자의 경우 platinum 제제에 기반한 고식적 일차 항암 요법에 비하여 gefitinib (Iressaⓡ)를 투여한 군에서 무병생존율의 연장을 보였다. 이러한 사실들은, EGFR 변이를 갖는 폐 선암종에서 악성 종양 세포의 특성을 유지, 보존할 수 있는 능력은 특정 “암유전자 변이” 에 직접적으로 의존하는 것을 의미하며 이러한 현상을 암유전자 중독 (oncogene addiction)으로 설명할 수 있다. EGFR 이외에도 2007년 EML4-ALK 유전자 전위 현상이 특정 폐암 환자군에서 강력한 발암 인자로 밝혀졌고, ALK TKI (PF-02341066, crizotinib)를 이용한 초기 임상 시험에서 현저한 종양 억제 효과를 보여 EGFR 이후 폐암 치료에 있어서 효과가 검증된 유력한 biomarker로 떠올랐다. 그 외 K-ras, B-raf, c-erbB2, MET 등의 유전자 변이가 폐암 발생에 관여하는 것으로 알려져 있다. 이러한 지식의 축적과 임상적 경험이 폐암을 진단하는 병리학 분야에 미치는 영향은 직접적이고도 현실적이라 할 수 있다. 즉, 병리 진단에 따라 치료 방침과 치료 약제의 선택이 결정될 뿐만 아니라, 특정 조직학적 유형의 폐암은 특정 치료제를 사용하였을 때 치명적 출혈 등의 부작용을 보이므로, 숙련된 병리의사가 전문적 지식을 동원하여 세분화된 조직학적 진단을 할 필요성이 그 어느 때 보다도 높아졌다. 따라서 분당서울대병원 병리과에서는 작은 생검 조직으로 병리의사에게 의뢰되는 폐암 환자들을 보다 정확한 진단의 바탕 위에 적절한 치료를 받을 수 있기 위하여 실제 진료 현장에서 최신 지견들을 적용하고 있다.
전통적으로 폐암은 크게 소세포암종과 비소세포암종으로 분류되어 왔는데, 이는 소세포암종은 수술보다는 전신 항암치료를 먼저 고려하는 반면, 비소세포암종의 경우 가능하면 외과적 절제를 시행하는 것이 치료 원칙이었기 때문이다. 또한, 수술이 불가능한 진행된 병기의 비소세포암종 환자들에게 약물 치료를 하는 경우 조직학적 아형과 무관하게 platinum 기반의 고식적 항암치료제가 공통적으로 쓰여졌기 때문이다. 그러나, 최근 새로운 약제들이 개발되고 임상 시험을 거치면서, 특정 항암 치료 약물을 사용하였을 때, 폐암의 병리조직학적 유형에 따라 임상적 반응이 유의하게 차이가 있음이 알려지게 되었다. 예를 들어, pemetrexed의 경우 선암종에는 종양 성장의 억제 효과를 보이지만, 편평상피세포암종 환자에 투여하였을 경우 기존의 항암치료약물에 비하여 우수성이 입증되지 않았고, anti-VEGF인자인 Bevacizumab의 경우 편평상피세포암종에서는 치명적 출혈을 일으키는 것이 알려져 금기 대상이 되었다. 즉, 이전에 분화가 좋지 않은 폐암을 비소세포암종으로 통칭하여 진단하던 것이 더 이상 유효하지 않게 된 것이다. 병리 의사의 역할이 폐암 환자의 조직학적 진단을 하는 데 국한되지 않고 치료 전략을 수립하는 데에도 영향을 미치게 되어, 개인맞춤화 의료시대를 맞이하여 정확하고 세분화된 병리조직학적 분류를 시행하는 것이 더욱 필요하다.
폐암환자의 80% 가량은 진단 당시 이미 암이 진행된 상태로 수술이 불가능 하므로, 작은 생검 조직을 이용하여 병리 의사가 진단하는 조직학적 분류 및 치료와 관련된 biomarker 발현 검사 결과를 바탕으로 향후 치료 방침이 정해지게 된다. 기관지 내시경이나 침생검을 통하여 얻는 작은 생검 조직이 전체 종양을 얼마나 대표할 것인가 하는 의문이 있음에도 불구하고, 병리의사는 생검을 통하여 얻은 소량의 암조직을 바탕으로 최대한 유용한 정보를 제공할 필요가 있다. 이를 위하여 여러 가지의 예후 관련 biomarker 발현 혹은 분자생물학적 검사를 고려할 때, 환자의 치료와 예후에 연관성이 높은 위주로 우선 순위를 정할 필요가 있다.
폐암에서 예후 및 치료제 연관 예측 인자로 검증된 biomarker는 EGFR 변이와 ALK 전위를 들 수 있다. 그 외에 치료제 반응을 예측할 수 있다고 알려진 biomarker로는 ERCC1 (platinum-based cytotoxic agents), RRM1 (Gemcitabine), Thymidylate synthase (pemetrexed) 발현 등이 알려져 있다. 소량의 생검 조직으로 이 모든 것을 그 때 그때 필요하다고 생각되어 시행하다 보면, 검사를 시행할 만한 조직이 남지 않게 되고, biomarker 검사를 위하여 또 다시 환자에게 침습적 생검을 시행하기란 쉽지 않다. 그러므로, 수술이 불가능하여 암조직의 채취가 어려운 환자의 경우 환자의 치료에 가장 필요하고, 임상적 특성을 종합하여 가장 의심되는 biomarker를 우선적으로 선택하여 시행하는 전략적 접근이 필수적이며, 이는 내과-영상의학과-병리과-흉부외과의 다학제간 협력이 전제가 되어야 한다. 분당서울대병원에서는, 수술이 불가능한 비소세포폐암, 특히 선암종 환자에서는 우선적으로 3㎛ 두께의 조직절편 4장을 제작하여 ALK, TTF-1, ERCC1에 대한 면역조직화학염색 3종을 시행하고, 혹시 시행하게 될지 모를 ALK FISH test검사를 대비하여 unstained section 1장을 남겨둔다.
그 후, 비교적 절편이 많이 필요한 EGFR 변이 검사용 unstained section (10㎛ 두께의 section 8장 정도)은 그 다음에 파라핀 블록을 절단하도록 하고 있다. 이 절차대로 하면, EGFR 변이 검사 시행 후 음성으로 나와서, 추가로 ALK 검사 등을 시행하려 할 때 조직이 모두 소모되어 검사를 시행할 수 없는 상황을 최소화할 수 있다. 면역조직화학염색의 결과는 대개 1-2일 이내로 결과가 나오므로, 그 결과를 바탕으로, 추가적으로 꼭 필요한 분자 진단 검사 절차를 시행할 수 있다. 이는 병리의사에 의하여 검증되고 표준화한 biomarker 결과를 활용할 때, 치료 방침 수립에 필요한 시간을 절약할 뿐만 아니라, 고가의 FISH 검사 등을 무작위로 하기 보다는 선별된 환자를 대상으로 시행함으로써 의료비 절감에도 도움이 된다.
폐의 선암종이 특히 주목 받고 있는 이유는, 비흡연자에서 가장 흔히 발생하는 폐암이며, 상대적으로 암유전자 변이와 강한 연관성을 가지고 있기 때문이다. 서론에서 간략히 소개한 바와 같이 폐암에서 EGFR 유전자 변이에 대한 경험은 폐암의 발생 기전에 대한 분자생물학적 지식의 진보와 더불어 진단과 치료 전략의 수립에 지대한 영향을 끼쳤다. 이에 대하여는 아래에서 다시 자세히 소개하겠지만, 일단 예후인자로 검증된 EGFR 변이 검사는 반드시 시행하기를 권장한다. 분당서울대병원 단일 기관의 경험에 의하면, 여성, 비흡연자, 선암종에서 papillary 혹은 lepidic (bronchioloalveolar) pattern 을 보이는 환자군의 70%에서 EGFR변이가 진단되어 기존에 보고된 빈도보다 상당히 높은 소견을 보였다. 그 뿐만 아니라, 남자 폐선암 환자의 34%, 흡연한 남자 선암종 환자의 29.4%에서 EGFR 변이가 진단되었다. EGFR TKI 치료 효과는 성별, 흡연 여부 혹은 조직학적 진단명보다 EGFR변이 여부에 더욱 연관성이 높다. 그러므로, 임상적 특성만으로 EGFR 변이 여부를 예단하기보다는 실제 폐암 조직에서 EGFR변이 검사를 시행하여 확인하는 것이 필요하다.
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Expression-based species deconvolution and realignment removes misalignment error in multispecies single-cell data.
BMC Bioinformatics
2022 ;23 (1) :157 -157
Jisun Lim, Yeon Bi Han, Soo Young Park, Soyeon Ahn, Hyojin Kim, Hyun Jung Kwon, Choon-Taek Lee, Sukki Cho, Jin-Haeng Chung
Gene Expression Profiles of Multiple Synchronous Lesions in Lung Adenocarcinoma.
Cells
2021 ;10 (12)
Hee Young Na, Jeong Hwan Park, Sun Ah Shin, Sejoon Lee, Heonyi Lee, Heejoon Chae, HoKyung Choung, Namju Kim, Jin-Haeng Chung, Ji Eun Kim
Targeted Sequencing Revealed Distinct Mutational Profiles of Ocular and Extraocular Sebaceous Carcinomas.
Cancers (Basel)
2021 ;13 (19)
Mincheol Chae, Jae Hyun Jeon, Jin-Haeng Chung, So Young Lee, Wan Jin Hwang, Woohyun Jung, Yoohwa Hwang, Sukki Cho, Kwhanmien Kim, Sanghoon Jheon
Prognostic significance of tumor spread through air spaces in patients with stage IA part-solid lung adenocarcinoma after sublobar resection.
Lung Cancer
2021 ;152 :21 -26
Yeon Bi Han, Hyojin Kim, Mari Mino-Kenudson, Sukki Cho, Hyun Jung Kwon, Ki Rim Lee, Soohyeon Kwon, Jeonghyo Lee, Kwhanmien Kim, Sanghoon Jheon, Choon-Taek Lee, Jong-Seok Lee, Woong Kook, Jin-Haeng Chung
Tumor spread through air spaces (STAS): prognostic significance of grading in non-small cell lung cancer.
Mod Pathol
2021 ;34 (3) :549 -561
Eun Hee Jung, Hee Ryeong Jang, Se Hyun Kim, Koung Jin Suh, Yu Jung Kim, Ju-Hyun Lee, Jin-Haeng Chung, Miso Kim, Bhumsuk Keam, Tae Min Kim, Dong-Wan Kim, Dae Seog Heo, Jong Seok Lee
Tumor LAG-3 and NY-ESO-1 expression predict durable clinical benefits of immune checkpoint inhibitors in advanced non-small cell lung cancer.
Thorac Cancer
2021 ;12 (5) :619 -630
Beatrice Chia-Hui Shih, Jae Hyun Jeon, Jin-Haeng Chung, Hyun Jung Kwon, Jeong Hoon Lee, Woohyun Jung, Yoohwa Hwang, Sukki Cho, Kwhanmien Kim, Sanghoon Jheon
Prognostic Significance of the Extranodal Extension of Regional Lymph Nodes in Stage III-N2 Non-Small-Cell Lung Cancer after Curative Resection.
J Clin Med
2021 ;10 (15)
Won-Gun Kwack, Yoon-Je Lee, Eun-Young Eo, Jin-Haeng Chung, Jae-Ho Lee, Young-Jae Cho
Simultaneous Pretreatment of Aspirin and Omega-3 Fatty Acid Attenuates Nuclear Factor-κB Activation in a Murine Model with Ventilator-Induced Lung Injury.
Nutrients
2021 ;13 (7)
So Young Lee, Jae Hyun Jeon, Woohyun Jung, Mincheol Chae, Wan Jin Hwang, Yoohwa Hwang, Sukki Cho, Jin-Haeng Chung, Kwhanmien Kim, Sanghoon Jheon
Predictive Factors for Lymph Node Metastasis in Clinical Stage I Part-Solid Lung Adenocarcinoma.
Ann Thorac Surg
2021 ;111 (2) :456 -462
Yeon Wook Kim, Byoung Soo Kwon, Sung Yoon Lim, Yeon Joo Lee, Jong Sun Park, Young-Jae Cho, Ho Il Yoon, Kyung Won Lee, Jae Ho Lee, Jin-Haeng Chung, Eunjeong Ji, Choon-Taek Lee
Lung cancer probability and clinical outcomes of baseline and new subsolid nodules detected on low-dose CT screening.
Thorax
2021 ;76 (10) :980 -988
Mari Mino-Kenudson, Nolwenn Le Stang, Jillian B Daigneault, Andrew G Nicholson, Wendy A Cooper, Anja C Roden, Andre L Moreira, Erik Thunnissen, Mauro Papotti, Giuseppe Pelosi, Noriko Motoi, Claudia Poleri, Elisabeth Brambilla, Mary Redman, Deepali Jain, Sanja Dacic, Yasushi Yatabe, Ming Sound Tsao, Fernando Lopez-Rios, Johan Botling, Gang Chen, Teh-Ying Chou, Fred R Hirsch, Mary Beth Beasley, Alain Borczuk, Lukas Bubendorf, Jin-Haeng Chung, David Hwang, Dongmei Lin, John Longshore, Masayuki Noguchi, Natasha Rekhtman, Lynette Sholl, William Travis, Akihiko Yoshida, Murry W Wynes, Ignacio I Wistuba, Keith M Kerr, Sylvie Lantuejoul
The International Association for the Study of Lung Cancer Global Survey on Programmed Death-Ligand 1 Testing for NSCLC.
J Thorac Oncol
2021 ;16 (4) :686 -696
Hwayoung Song, Sung Hyun Yoon, Junghoon Kim, Jihang Kim, Kyoung Won Lee, Woojoo Lee, Seungjae Lee, Kwhanmien Kim, Choon-Taek Lee, Jin-Haeng Chung, Kyung Hee Lee
Application of N Descriptors Proposed by the International Association for the Study of Lung Cancer in Clinical Staging.
Radiology
2021 ;300 (2) :450 -457
Woohyun Jung, Jin-Haeng Chung, Sungwon Yum, Kwhanmien Kim, Choon Taek Lee, Sanghoon Jheon, Sukki Cho
The differential prognostic impact of spread through air spaces in early-stage lung adenocarcinoma after lobectomy according to the pT descriptor.
J Thorac Cardiovasc Surg
2020
Emina Torlakovic, Hyun J Lim, Julien Adam, Penny Barnes, Gilbert Bigras, Anthony W H Chan, Carol C Cheung, Jin-Haeng Chung, Christian Couture, Pierre O Fiset, Daichi Fujimoto, Gang Han, Fred R Hirsch, Marius Ilie, Diana Ionescu, Chao Li, Enrico Munari, Katsuhiro Okuda, Marianne J Ratcliffe, David L Rimm, Catherine Ross, Rasmus Røge, Andreas H Scheel, Ross A Soo, Paul E Swanson, Maria Tretiakova, Ka F To, Gilad W Vainer, Hangjun Wang, Zhaolin Xu, Dirk Zielinski, Ming-Sound Tsao
"Interchangeability" of PD-L1 immunohistochemistry assays: a meta-analysis of diagnostic accuracy.
Mod Pathol
2020 ;33 (1) :4 -17
KimKichun, LimCheong, KimGilhyang, ChungJin-Haeng, ChoYoung-Seok, ChoJun Hwan, SeoJae-Bin, ChungWoo-Young, OhSe-Jin, ChoiJae-Sung, KimJun-Sung, ParkJin Joo, SuhJung-Won, YounTae-Jin, ChaeIn-Ho, ChoiDong-Ju
Association of Plasma Marker of Oxidized Lipid with Histologic Plaque Instability in Patients with Peripheral Artery Disease.
Ann Vasc Surg
2020 ;66 :554 -565
Andre L Moreira, Paolo S S Ocampo, Yuhe Xia, Hua Zhong, Prudence A Russell, Yuko Minami, Wendy A Cooper, Akihiko Yoshida, Lukas Bubendorf, Mauro Papotti, Giuseppe Pelosi, Fernando Lopez-Rios, Keiko Kunitoki, Dana Ferrari-Light, Lynette M Sholl, Mary Beth Beasley, Alain Borczuk, Johan Botling, Elisabeth Brambilla, Gang Chen, Teh-Ying Chou, Jin-Haeng Chung, Sanja Dacic, Deepali Jain, Fred R Hirsch, David Hwang, Sylvie Lantuejoul, Dongmei Lin, John W Longshore, Noriko Motoi, Masayuki Noguchi, Claudia Poleri, Natasha Rekhtman, Ming-Sound Tsao, Erik Thunnissen, William D Travis, Yasushi Yatabe, Anja C Roden, Jillian B Daigneault, Ignacio I Wistuba, Keith M Kerr, Harvey Pass, Andrew G Nicholson, Mari Mino-Kenudson
A Grading System for Invasive Pulmonary Adenocarcinoma: A Proposal From the International Association for the Study of Lung Cancer Pathology Committee.
J Thorac Oncol
2020 ;15 (10) :1599 -1610
LimSung Yoon, ChoYoung-Jae, KimDong Jung, KimJun Sung, JheonSanghoon, ChungJin Haeng, LeeJae Ho
Effects of Ultralow-Tidal-Volume Ventilation under Veno-Venous Extracorporeal Membrane Oxygenation in a Porcine Model with Ventilator-Induced Lung Injury.
Membranes (Basel)
2020 ;10 (12)
Joon Chul Jung, Seong-Ik Kim, Ho Young Hwang, Suk Ho Sohn, Jae Woong Choi, Jin-Haeng Chung, Jeong-Wook Seo, Ki-Bong Kim
Serial ultrastructural evaluation of myocardial ischemic injury after infusion of del Nido cardioplegia in the human heart.
J Thorac Cardiovasc Surg
2020
Soyeon Ahn, Jisun Lim, Soo Young Park, Hyojin Kim, Hyun Jung Kwon, Yeon Bi Han, Choon-Taek Lee, Sukki Cho, Jin-Haeng Chung
Genetic Alterations in Preinvasive Lung Synchronous Lesions.
Cancer Res Treat
2020 ;52 (4) :1120 -1134
Soohyeon Kwon, Soon-Hyun Ahn, Woo-Jin Jeong, Young Ho Jung, Yun Jung Bae, Jin Ho Paik, Jin-Haeng Chung, Hyojin Kim
Estrogen receptor α as a predictive biomarker for survival in human papillomavirus-positive oropharyngeal squamous cell carcinoma.
J Transl Med
2020 ;18 (1) :240 -240
Lynette M Sholl, Fred R Hirsch, David Hwang, Johan Botling, Fernando Lopez-Rios, Lukas Bubendorf, Mari Mino-Kenudson, Anja C Roden, Mary Beth Beasley, Alain Borczuk, Elisabeth Brambilla, Gang Chen, Teh-Ying Chou, Jin-Haeng Chung, Wendy A Cooper, Sanja Dacic, Sylvie Lantuejoul, Deepali Jain, Dongmei Lin, Yuko Minami, Andre Moreira, Andrew G Nicholson, Masayuki Noguchi, Mauro Papotti, Giuseppe Pelosi, Claudia Poleri, Natasha Rekhtman, Ming-Sound Tsao, Erik Thunnissen, William Travis, Yasushi Yatabe, Akihiko Yoshida, Jillian B Daigneault, Ahmet Zehir, Solange Peters, Ignacio I Wistuba, Keith M Kerr, John W Longshore
The Promises and Challenges of Tumor Mutation Burden as an Immunotherapy Biomarker: A Perspective from the International Association for the Study of Lung Cancer Pathology Committee.
J Thorac Oncol
2020 ;15 (9) :1409 -1424
Woohyun Jung, Sukki Cho, Sungwon Yum, Jin-Haeng Chung, Kyung Won Lee, Kwhanmien Kim, Choon Taek Lee, Sanghoon Jheon
Stepwise Disease Progression Model of Subsolid Lung Adenocarcinoma with Cystic Airspaces.
Ann Surg Oncol
2020 ;27 (11) :4394 -4403
Sylvie Lantuejoul, Ming Sound-Tsao, Wendy A Cooper, Nicolas Girard, Fred R Hirsch, Anja C Roden, Fernando Lopez-Rios, Deepali Jain, Teh-Ying Chou, Noriko Motoi, Keith M Kerr, Yasushi Yatabe, Elisabeth Brambilla, John Longshore, Mauro Papotti, Lynette M Sholl, Erik Thunnissen, Natasha Rekhtman, Alain Borczuk, Lukas Bubendorf, Yuko Minami, Mary Beth Beasley, Johan Botling, Gang Chen, Jin-Haeng Chung, Sanja Dacic, David Hwang, Dongmei Lin, Andre Moreira, Andrew G Nicholson, Masayuki Noguchi, Giuseppe Pelosi, Claudia Poleri, William Travis, Akihiko Yoshida, Jillian B Daigneault, Ignacio I Wistuba, Mari Mino-Kenudson
PD-L1 Testing for Lung Cancer in 2019: Perspective From the IASLC Pathology Committee.
J Thorac Oncol
2020 ;15 (4) :499 -519
Han Yeon Bi, Kwon Hyun Jung, Park Soo Young, Kim Eun-Sun, Kim Hyojin, Chung Jin-Haeng
Human Leukocyte Antigen Class I and Programmed Death-Ligand 1 Coexpression Is an Independent Poor Prognostic Factor in Adenocarcinoma of the Lung
J PATHOL TRANSL MED
2019 ;53 (2) :86 -93
Moon Sung Woo, Park Moo Suk, Kim Young Sam, Jang Joon, Lee Jae Ho, Lee Choon-Taek, Chung Jin-Haeng, Shim Hyo Sup, Lee Kyung Won, Kim Seung-Seob, Lee Sang Hoon, Yoon Ho Il
Combined pulmonary fibrosis and emphysema and idiopathic pulmonary fibrosis in non-small cell lung cancer: impact on survival and acute exacerbation
BMC PULM MED
2019 ;19 (1)
Yatabe Yasushi, Dacic Sanja, Borczuk Alain C, Warth Arne, Russell Prudence A, Lantuejoul Sylvie, Beasley Mary Beth, Thunnissen Erik, Pelosi Giuseppe, Rekhtman Natasha, Bubendorf Lukas, Mino-Kenudson Mari, Yoshida Akihiko, Geisinger Kim R, Noguchi Masayuki, Chirieac Lucian R, Bolting Johan, Chung Jin-Haeng, Chou Teh-Ying, Chen Gang, Poleri Claudia, Lopez-Rios Fernando, Papotti Mauro, Sholl Lynette M, Roden Anja C, Travis William D, Hirsch Fred R, Kerr Keith M, Tsao Ming-Sound, Nicholson Andrew G, Wistuba Ignacio, Moreira Andre L
Best Practices Recommendations for Diagnostic Immunohistochemistry in Lung Cancer
J THORAC ONCOL
2019 ;14 (3) :377 -407
Han SongYi, Lee Sang Hoon, Lee Yeon Joo, Park Jong Sun, Cho Young-Jae, Yoon Ho Il, Lee Jae-Ho, Lee Choon-Taek, Chung Jin-Haeng, Lee Kyung Won
Prognosis of non-small-cell lung cancer in patients with idiopathic pulmonary fibrosis
SCI REP-UK
2019 ;9 (1)
Shih Angela R, Uruga Hironori, Bozkurtlar Emine, Chung Jin-Haeng, Hariri Lida P, Minami Yuko, Wang He, Yoshizawa Akihiko, Muzikansky Alona, Moreira Andre L, Mino-Kenudson Mari
Problems in the reproducibility of classification of small lung adenocarcinoma: an international interobserver study
HISTOPATHOLOGY
2019 ;75 (5) :649 -659
Kim Hyojin, Chung Jin-Haeng
PD-L1 Testing in Non-small Cell Lung Cancer: Past, Present, and Future
J Pathol Transl Med
2019 ;53 (4) :199 -206
Kim Hyung-Jun, Cho Jun Yeun, Lee Yeon Joo, Park Jong Sun, Cho Young-Jae, Yoon Ho Il, Chung Jin-Haeng, Cho Sukki, Kim Kwhanmien, Lee Kyung Won, Lee Jae Ho, Lee Choon-Taek
Clinical Significance of Pleural Attachment and Indentation of Subsolid Nodule Lung Cancer
CANCER RES TREAT
2019 ;51 (4) :1540 -1548
Shin Junghoon, Kim Se Hyun, Chung Jin-Haeng, Lee Kyu Sang, Suh Koung Jin, Lee Ji Yun, Kim Ji-Won, Lee Jeong-Ok, Kim Jin-Won, Kim Yu-Jung, Lee Keun-Wook, Kim Jee Hyun, Bang Soo-Mee, Lee Jong-Seok
Effect of Platinum-Based Chemotherapy on PD-L1 Expression on Tumor Cells in Non-small Cell Lung Cancer
CANCER RES TREAT
2019 ;51 (3) :1086 -1097
Kim Hyojin, Chung Jin-Haeng, Kwon Hyun Jung, Han Yeon Bi, Park Soo Young, Kim Eun Sun, Kim Se Hyun, Kim Yu Jung, Lee Jong Seok
Increased CD3+ T cells with a low FOXP3+/CD8+ T cell ratio can predict anti-PD-1 therapeutic response in non-small cell lung cancer patients
MODERN PATHOL
2019 ;32 (3) :367 -375
Kim Jeong-Whun, Huh Gene, Rhee Chae-Seo, Lee Chul Hee, Lee Jaebong, Chung Jin-Hang, Cho Sung-Woo
Unsupervised cluster analysis of chronic rhinosinusitis with nasal polyp using routinely available clinical markers and its implication in treatment outcomes
INT FORUM ALLERGY RH
2019 ;9 (1) :79 -86
Koh Jiwon, Lee Hye Seung, Nam Soo Kyung, Roh Hanseong, Kim Jonghyuk, Lee Byung-Chul, Kim Jin Won, Ahn Sang-Hoon, Park Do Joong, Kim Hyung-Ho, Park Kyoung Un, Chung Jin Haeng, Kim Woo Ho
Somatic mutational profiles of stage II and III gastric cancer according to tumor microenvironment immune type
GENE CHROMOSOME CANC
2019 ;58 (1) :12 -22
Chang Hyun, Yang Yaewon, Lee Jong-Seok, Jheon Sang-Hoon, Kim Yu Jung, Chung Jin-Haeng
Epidermal Growth Factor Receptor Gene Amplification Predicts Worse Outcome in Patients With Surgically Resected Nonadenocarcinoma Lung Cancer
CLIN LUNG CANCER
2019 ;20 (1) :7 -12.e1
Kim Hyojin, Paik Jin Ho, Yang Jeong Mi, Ahn Soon-Hyun, Jeong Woo-Jin, Chung Jin-Haeng
Potential Oncogenic Role and Prognostic Implication of MicroRNA-155-5p in Oral Squamous Cell Carcinoma
ANTICANCER RES
2018 ;38 (9) :5193 -5200
Park Eunhyang, Ahn Soyeon, Kim Hyojin, Park Soo Young, Lim Jisun, Kwon Hyun Jung, Han Yeon Bi, Lee Choon-Taek, Cho Sukki, Chung Jin-Haeng
Targeted Sequencing Analysis of Pulmonary Adenocarcinoma with Multiple Synchronous Ground-Glass/Lepidic Nodules
J THORAC ONCOL
2018 ;13 (11) :1776 -1783
Kim Hyojin, Kwon Hyun Jung, Park Soo Young, Park Youngmi, Park Eunhyang, Chung Jin-Haeng
Clinicopathological analysis and prognostic significance of programmed cell death-ligand 1 protein and mRNA expression in non-small cell lung cancer
PLOS ONE
2018 ;13 (6)
Tsao Ming Sound, Hirsch Fred R, Kerr Keith M, Kockx Mark, Beasley Mary-Beth, Borczuk Alain C, Botling Johan, Bubendorf Lukas, Chirieac Lucian, Chen Gang, Chou Teh-Ying, Chung Jin-Haeng, Dacic Sanja, Lantuejoul Sylvie, Mino-Kenudson Mari, Moreira Andre L, Nicholson Andrew G, Noguchi Masayuki, Pelosi Giuseppe, Poleri Claudia, Russell Prudence A, Sauter Jennifer, Thunnissen Erik, Wistuba Ignacio, Yu Hui, Wynes Murry W, Pintilie Melania, Yatabe Yasushi
PD-L1 Immunohistochemistry Comparability Study in Real-Life Clinical Samples: Results of Blueprint Phase 2 Project
J THORAC ONCOL
2018 ;13 (9) :1302 -1311
Shin Junghoon, Lee Kyu Sang, Kim Se Hyun, Yoh Kyung Ah, Cho Hyun Jin, Choi Moon Ki, Kim Yu Jung, Chung Jin-Haeng, Cho Sukki, Kim Kwhanmien, Jheon Sanghoon, Yoon Ho Il, Lee Jae Ho, Lee Choon-Taek, Lee Jong Seok
Prognostic Impact of DNA Repair Protein Expression in Non-Small Cell Lung Cancers Treated with Platinum-Based Chemotherapy and Subsequent Curative Lung Resection
ONCOLOGY-BASEL
2018 ;95 (1) :20 -30
Jo Jaemin, Kim Se Hyun, Lee Jong Seok, Kim Yu Jung, Lee Juhyun, Kim Miso, Keam Bhumsuk, Kim Tae Min, Kim Dong Wan, Heo Dae Seog, Chung Jin Haeng, Jeon Yoon Kyung
Efficacy of Pemetrexed-based Chemotherapy in Comparison to Non-Pemetrexed-based Chemotherapy in Advanced, ALK+ Non-Small Cell Lung Cancer
YONSEI MED J
2018 ;59 (2) :202 -210
Ahn Hyungwoo, Lee Kyung Won, Lee Kyung Hee, Kim Jihang, Kim Kwhanmien, Chung Jin-Haeng, Lee Choon-Taek
Effect of computed tomography window settings and reconstruction plane on 8th edition T-stage classification in patients with lung adenocarcinoma manifesting as a subsolid nodule
EUR J RADIOL
2018 ;98 :130 -135
Nicholson Andrew G, Torkko Kathleen, Viola Patrizia, Duhig Edwina, Geisinger Kim, Borczuk Alain C, Hiroshima Kenzo, Tsao Ming S, Warth Arne, Lantuejoul Sylvie, Russell Prudence A, Thunnissen Erik, Marchevsky Alberto, Mino-Kenudson Mari, Beasley Mary Beth, Botling Johan, Dacic Sanja, Yatabe Yasushi, Noguchi Masayuki, Travis William D, Kerr Keith, Hirsch Fred R, Chirieac Lucian R, Wistuba Ignacio I, Moreira Andre, Chung Jin-Haeng, Chou Teh Ying, Bubendorf Lukas, Chen Gang, Pelosi Giuseppe, Poleri Claudia, Detterbeck Frank C, Franklin Wilbur A
Interobserver Variation among Pathologists and Refinement of Criteria in Distinguishing Separate Primary Tumors from Intrapulmonary Metastases in Lung
J THORAC ONCOL
2018 ;13 (2) :205 -217
Yi Eunjue, Bae Mi-Kyeong, Cho Sukki, Chung Jin-Haeng, Jheon Sanghoon, Kim Kwhanmien
Pathological prognostic factors of recurrence in early stage lung adenocarcinoma
ANZ J SURG
2018 ;88 (4) :327 -331
Ha You-Jung, Choi Yong Seok, Kang Eun Ha, Chung Jin-Haeng, Cha Seunghee, Song Yeong Wook, Lee Yun Jong
Increased expression of interferon-λ in minor salivary glands of patients with primary Sjogren's syndrome and its synergic effect with interferon-α on salivary gland epithelial cells
CLIN EXP RHEUMATOL
2018 ;36 Suppl 112 (3) :31 -40
Ahn Hyein, Kwon Hyun Jung, Park Eunhyang, Kim Hyojin, Chung Jin-Haeng
Osteosarcomatous Differentiation in Rebiopsy Specimens of Pulmonary Adenocarcinoma with EGFR-TKI Resistance
J Pathol Transl Med
2018 ;52 (2) :130 -132
Chung Jin-Haeng, Kim Hyojin, Kwon Hyun Jung, Park Soo Young, Park Eunhyang
PD-L1 immunohistochemical assays for assessment of therapeutic strategies involving immune checkpoint inhibitors in non-small cell lung cancer: a comparative study
Oncotarget
2017 ;8 (58) :98524 -98532
Ahn Hyein, Paik Jin Ho, Yang Jeong Mi, Kim Hyojin, Chung Jin-Haeng, Ahn Soon-Hyun, Jeong Woo-Jin
Clinicopathologic implications of the miR-197/PD-L1 axis in oral squamous cell carcinoma
Oncotarget
2017 ;8 (39) :66178 -66194
Yi Eunjue, Han Sung-Mi, Chang Ji-Eun, Kim Hong-Tae, Kim Jong-Ki, Seo Seung-Jun, Chung Jin-Haeng, Jheon Sanghoon
Synchrotron tomographic images from human lung adenocarcinoma: Three-dimensional reconstruction and histologic correlations
MICROSC RES TECHNIQ
2017 ;80 (10) :1141 -1148
Lim Sun Min, Cho Byoung Chul, Kim Hye Ryun, Lee Jong-Seok, Lee Ki Hyeong, Lee Yun-Gyoo, Min Young Joo, Cho Eun Kyung, Lee Sung Sook, Kim Bong-Seog, Choi Moon Young, Shim Hyo Sup, Chung Jin-Haeng, La Choi Yoon, Lee Min Jeong, Kim Maria, Kim Joo-Hang, Ali Siraj M, Ahn Myung-Ju
Open-Label, Multicenter, Phase II Study of Ceritinib in Patients With Non-Small-Cell Lung Cancer Harboring ROS1 Rearrangement
J CLIN ONCOL
2017 ;35 (23) :2613 -2618
Shim Hyo Sup, Choi Yoon-La, Kim Lucia, Chang Sunhee, Kim Wan-Seop, Roh Mee Sook, Kim Tae-Jung, Ha Seung Yeon, Chung Jin-Haeng, Jang Se Jin, Lee Geon Kook, ,
Molecular Testing of Lung Cancers
J Pathol Transl Med
2017 ;51 (3) :242 -254
Shin Kyung Wook, Cho Sukki, Chung Jin-Haeng, Lee Kyung Won, Lee Choon-Taek, Kim Kwhanmien, Jheon Sanghoon
Comparison of Prognosis of Solid and Part-Solid Node-Negative Adenocarcinoma With the Same Invasive Component Size
ANN THORAC SURG
2017 ;103 (5) :1654 -1660
Thunnissen Erik, Borczuk Alain C, Flieder Douglas B, Witte Birgit, Beasley Mary Beth, Chung Jin-Haeng, Dacic Sanja, Lantuejoul Sylvie, Russell Prudence A, den Bakker Michael, Botling Johan, Brambilla Elisabeth, de Cuba Erienne, Geisinger Kim R, Hiroshima Kenzo, Marchevsky Alberto M, Minami Yuko, Moreira Andre, Nicholson Andrew G, Yoshida Akihiko, Tsao Ming-Sound, Warth Arne, Duhig Edwina, Chen Gang, Matsuno Yoshihiro, Travis William D, Butnor Kelly, Cooper Wendy, Mino-Kenudson Mari, Motoi Noriko, Poleri Claudia, Pelosi Giuseppe, Kerr Keith, Aisner Seena C, Ishikawa Yuichi, Buettner Reinhard H, Keino Naoto, Yatabe Yasushi, Noguchi Masayuki
The Use of Immunohistochemistry Improves the Diagnosis of Small Cell Lung Cancer and Its Differential Diagnosis. An International Reproducibility Study in a Demanding Set of Cases
J THORAC ONCOL
2017 ;12 (2) :334 -346
Kim Hyojin, Paik Jin Ho, Yang Jeong Mi, Jin Yan, Jheon Sanghoon, Kim Kwhanmien, Lee Choon Taek, Chung Jin-Haeng
MicroRNA expression profiles and clinicopathological implications in lung adenocarcinoma according to EGFR, KRAS, and ALK status
Oncotarget
2017 ;8 (5) :8484 -8498
Ihn Myong Hoon, Kim Duck-Woo, Cho Sukki, Oh Heung-Kwon, Jheon Sanghoon, Kim Kwhanmien, Shin Eun, Lee Hye Seung, Chung Jin-Haeng, Kang Sung-Bum
Curative Resection for Metachronous Pulmonary Metastases from Colorectal Cancer: Analysis of Survival Rates and Prognostic Factors
CANCER RES TREAT
2017 ;49 (1) :104 -115
Jin Jiajia, Zhan Ping, Qian Hong, Wang Xiaoxia, Katoh Masaru, Phan Kevin, Chung Jin-Haeng, Lv Tangfeng, Song Yong,
Prognostic value of wingless-type proteins in non-small cell lung cancer patients: a meta-analysis
Transl Lung Cancer Res
2016 ;5 (4) :436 -442
Na Hee Young, Choe Ji-Young, Shin Seon Ah, Choung Ho-Kyung, Oh Sohee, Chung Jin-Haeng, Park Mira, Kim Ji Eun
Proposal of a Provisional Classification of Sebaceous Carcinoma Based on Hormone Receptor Expression and HER2 Status
AM J SURG PATHOL
2016 ;40 (12) :1622 -1630
Chang Hyun, Lee Jong-Seok, Oh Jisu, Zhang Xianglan, Kim Yu Jung, Lee Jae Ho, Lee Choon-Taek, Chung Jin-Haeng
EGFR protein expression using a specific intracellular domain antibody and PTEN and clinical outcomes in squamous cell lung cancer patients with EGFR-tyrosine kinase inhibitor therapy
ONCOTARGETS THER
2016 ;9 :5153 -5162
Park Eunhyang, Chung Jin-Haeng, Park Soo Young, Sun Ping-Li, Jin Yan, Kim Ji Eun, Jheon Sanghoon, Kim Kwhanmien, Lee Choon Taek, Kim Hyojin
Prognostic significance of stem cell-related marker expression and its correlation with histologic subtypes in lung adenocarcinoma
ONCOTARGET
2016 ;7 (27) :42502 -42512
Yun Sumi, Sun Ping-Li, Jin Yan, Kim Hyojin, Park Eunhyang, Park Soo Young, Lee Kyuho, Lee Kyoungyul, Chung Jin-Haeng
Aquaporin 1 Is an Independent Marker of Poor Prognosis in Lung Adenocarcinoma
J Pathol Transl Med
2016 ;50 (4) :251 -257
Hong Su Jin, Kim Tae Jung, Choi Yo Won, Park Jeong-Soo, Chung Jin-Haeng, Lee Kyung Won
Radiogenomic correlation in lung adenocarcinoma with epidermal growth factor receptor mutations: Imaging features and histological subtypes
EUR RADIOL
2016 ;26 (10) :3660 -3668
Kim Tae Jung, Lee Choon-Taek, Jheon Sang Hoon, Park Jeong-Soo, Chung Jin-Haeng
Radiologic Characteristics of Surgically Resected Non-Small Cell Lung Cancer With ALK Rearrangement or EGFR Mutations
ANN THORAC SURG
2016 ;101 (2) :473 -480
Sun Ping-Li, Jin Yan, Park Soo Young, Kim Hyojin, Park Eunhyang, Jheon Sanghoon, Kim Kwhanmien, Lee Choon-Taek, Chung Jin-Haeng
Expression of Na+-K+-2Cl- cotransporter isoform 1 (NKCC1) predicts poor prognosis in lung adenocarcinoma and EGFR-mutated adenocarcinoma patients
QJM
2016 ;109 (4) :237 -244
Park Eunhyang, Park Soo Young, Kim Hyojin, Sun Ping-Li, Jin Yan, Cho Suk Ki, Kim Kwhanmien, Lee Choon-Taek, Chung Jin-Haeng
Membranous Insulin-like Growth Factor-1 Receptor (IGF1R) Expression Is Predictive of Poor Prognosis in Patients with Epidermal Growth Factor Receptor (EGFR)-Mutant Lung Adenocarcinoma
J Pathol Transl Med
2015 ;49 (5) :382 -388
Jin Yan, Sun Ping-Li, Park Soo Young, Kim Hyojin, Park Eunhyang, Kim Gilhyang, Cho Sukki, Kim Kwhanmien, Lee Choon-Taek, Chung Jin-Haeng
Frequent aerogenous spread with decreased E-cadherin expression of ROS1-rearranged lung cancer predicts poor disease-free survival
LUNG CANCER
2015 ;89 (3) :343 -349
Yang Hee Chul, Kim Hyeong Ryul, Jheon Sanghoon, Kim Kwhanmien, Cho Sukki, Ahn Soyeon, Lee Ho-Young, Chung Jin-Haeng, Chung Kyung Young, Bae Mi Kyung, Park Seong Yong, Kim Dong Kwan, Choi Se Hoon, Zo Jae Ill, Kim Moon Soo, Lee Jong Mog, Kim Jhingook, Shim Young Mog, Na Kook Joo, Yun Ju Sik, Park Jae Yong
Recurrence Risk-Scoring Model for Stage I Adenocarcinoma of the Lung
ANN SURG ONCOL
2015 ;22 (12) :4089 -4097
Rhee Ye-Young, Lee Tae-Hun, Song Young Seok, Wen Xianyu, Kim Hyojin, Jheon Sanghoon, Lee Choon-Taek, Kim Jei, Cho Nam-Yun, Chung Jin Haeng, Kang Gyeong Hoon
Prognostic significance of promoter CpG island hypermethylation and repetitive DNA hypomethylation in stage I lung adenocarcinoma
VIRCHOWS ARCH
2015 ;466 (6) :675 -683
Xu Xianhua, Kim Ji Eun, Sun Ping-Li, Yoo Seol Bong, Kim Hyojin, Jin Yan, Chung Jin-Haeng
Immunohistochemical demonstration of alteration of β-catenin during tumor metastasis by different mechanisms according to histology in lung cancer
EXP THER MED
2015 ;9 (2) :311 -318
Yatabe Yasushi, Kerr Keith M, Utomo Ahmad, Rajadurai Pathmanathan, Tran Van Khanh, Du Xiang, Chou Teh-Ying, Enriquez Ma Luisa D, Lee Geon Kook, Iqbal Jabed, Shuangshoti Shanop, Chung Jin-Haeng, Hagiwara Koichi, Liang Zhiyong, Normanno Nicola, Park Keunchil, Toyooka Shinichi, Tsai Chun-Ming, Waring Paul, Zhang Li, McCormack Rose, Ratcliffe Marianne, Itoh Yohji, Sugeno Masatoshi, Mok Tony
EGFR mutation testing practices within the Asia Pacific region: results of a multicenter diagnostic survey
J THORAC ONCOL
2015 ;10 (3) :438 -445
Jin Yan, Sun Ping-Li, Kim Hyojin, Park Eunhyang, Shim Hyo Sup, Jheon Sanghoon, Kim Kwhanmien, Lee Choon-Taek, Chung Jin-Haeng
ROS1 gene rearrangement and copy number gain in non-small cell lung cancer
VIRCHOWS ARCH
2015 ;466 (1) :45 -52
Thunnissen Erik, Noguchi Masayuki, Aisner Seena, Beasley Mary Beth, Brambilla Elisabeth, Chirieac Lucian R, Chung Jin-Haeng, Dacic Sanja, Geisinger Kim R, Hirsch Fred R, Ishikawa Yuichi, Kerr Keith M, Lantejoul Sylvie, Matsuno Yoshiro, Minami Yuko, Moreira Andre L, Pelosi Giuseppe, Petersen Iver, Roggli Victor, Travis William D, Wistuba Ignacio, Yatabe Yasushi, Dziadziuszko Rafal, Witte Birgit, Tsao Ming-Sound, Nicholson Andrew G
Reproducibility of histopathological diagnosis in poorly differentiated NSCLC: an international multiobserver study
J THORAC ONCOL
2014 ;9 (9) :1354 -1362
Kim Miso, Chang Hyun, Lee Jong Seok, Yang Hee Chul, Kim Yu Jung, Lee Choon-Taek, Lee Jae-Ho, Jheon Sanghoon, Kim Kwhanmien, Chung Jin-Haeng
Preoperative thrombocytosis is a significant unfavorable prognostic factor for patients with resectable non-small cell lung cancer
WORLD J SURG ONCOL
2014 ;12
Seo An Na, Park Tae-In, Jin Yan, Sun Ping-Li, Kim Hyojin, Chang Hyun, Chung Jin-Haeng
Novel EGFR mutation-specific antibodies for lung adenocarcinoma: highly specific but not sensitive detection of an E746_A750 deletion in exon 19 and an L858R mutation in exon 21 by immunohistochemistry
LUNG CANCER
2014 ;83 (3) :316 -323
Jin Yan, Sun Ping-Li, Lee Choon-Taek, Jheon Sanghoon, Seo An Na, Kim Hyojin, Chung Jin-Haeng
MET gene copy number gain is an independent poor prognostic marker in Korean stage I lung adenocarcinomas
ANN SURG ONCOL
2014 ;21 (2) :621 -628
Cho Han-Kyu, Koo Ja-Won, Lee Yun Jong, Chung Jin-Haeng
In Reply: IgG4 Related Disease and Sensorineural Hearing Loss
CLIN EXP OTORHINOLAR
2014 ;7 (3) :238 -239
Park Eunhyang, Kim Hyojin, Jung Kyu Whan, Chung Jin-Haeng
Heterotopic pancreas in omphalomesenteric duct remnant results in persistent umbilical discharge
Korean J Pathol
2014 ;48 (4) :323 -326
Park Tai Sun, Choi Chang-Min, Kim Hye-Ryoun, Koh Jae Soo, Jang Seung Hun, Hwang Yong Il, Yoon Ho Il, Chung Jin-Haeng, Kim Cheol Hyeon, Kim Sung-Soo, Kim Woo Sung, Jo Jungmin, Lee Jae Cheol
Heat shock protein 70 as a predictive marker for platinum-based adjuvant chemotherapy in patients with resected non-small cell lung cancer
LUNG CANCER
2014 ;86 (2) :262 -267
Kim Hyojin, Lee Geon Kook, Shim Hyo Sup, Kim Lucia, Kim Tae-Jung, Kwon Kun Young, Chung Jin-Haeng,
Guideline Recommendations for Testing of ALK Gene Rearrangement in Lung Cancer: A Proposal of the Korean Cardiopulmonary Pathology Study Group
Korean J Pathol
2014 ;48 (1) :1 -9
Seo An Na, Jin Yan, Lee Hee Jin, Sun Ping-Li, Kim Hyojin, Jheon Sanghoon, Kim Kwhanmien, Lee Choon-Taek, Chung Jin-Haeng
FGFR1 amplification is associated with poor prognosis and smoking in non-small-cell lung cancer
VIRCHOWS ARCH
2014 ;465 (5) :547 -558
Ko Sung-Jun, Lee Choon-Taek, Lee Yeon Joo, Park Jong Sun, Cho Young-Jae, Yoon Ho Il, Chung Jin-Haeng, Kim Tae Jung, Lee Kyung Won, Kim Kwhanmien, Jheon Sanghoon, Kim Hyojin, Lee Jae Ho
Epidermal growth factor receptor mutations and anaplastic lymphoma kinase rearrangements in lung cancer with nodular ground-glass opacity
BMC CANCER
2014 ;14
Sun Ping-Li, Kim Ji Eun, Yoo Seol Bong, Kim Hyojin, Jin Yan, Jheon Sanghoon, Kim Kwhanmien, Lee Choon Taek, Chung Jin-Haeng
Cytoplasmic YAP expression is associated with prolonged survival in patients with lung adenocarcinomas and epidermal growth factor receptor tyrosine kinase inhibitor treatment
ANN SURG ONCOL
2014 ;21 Suppl 4 :S610 -S618
Kang Hyo Jae, Lee Choon-Taek, Lim Hyo-Jeong, Park Jong Sun, Cho Young-Jae, Yoon Ho-Il, Chung Jin-Haeng, Lee Jae Ho
Comparison of clinical characteristics between patients with ALK-positive and EGFR-positive lung adenocarcinoma
RESP MED
2014 ;108 (2) :388 -394
Seo A N, Paik J H, Yang J M, Kim H, Jheon S, Kim K, Lee C T, Jin Y, Yun S, Chung J-H
Clinicopathologic and prognostic significance of c-MYC copy number gain in lung adenocarcinomas
BRIT J CANCER
2014 ;110 (11) :2688 -2699
Lee Youkyung, Lee Kyung Won, Chung Jin-Haeng, Kim Sang Eun, Kim Tae Jung
Adenosquamous carcinoma of the lung: CT, FDG PET, and clinicopathologic findings
CLIN NUCL MED
2014 ;39 (2) :107 -112
Koh Jaemoon, Chung Doo Hyun, Go Heounjeong, Kim Moon-Young, Jeon Yoon Kyung, Chung Jin-Haeng
A comprehensive immunohistochemistry algorithm for the histological subtyping of small biopsies obtained from non-small cell lung cancers
HISTOPATHOLOGY
2014 ;65 (6) :868 -878
Lee Hyun Ju, Xu Xianhua, Kim Hyojin, Jin Yan, Sun Pingli, Kim Ji Eun, Chung Jin-Haeng
Comparison of Direct Sequencing, PNA Clamping-Real Time Polymerase Chain Reaction, and Pyrosequencing Methods for the Detection of EGFR Mutations in Non-small Cell Lung Carcinoma and the Correlation with Clinical Responses to EGFR Tyrosine Kinase Inhibitor Treatment
Korean J Pathol
2013 ;47 (1) :52 -60
CHUNG JIN HAENG, 황성일, 이학종, 김길중, 정현숙, 전종준
The Correlations of Parameters Using Contrast Enhanced Ultrasonography in the Evaluation of Prostate Cancer Angiogenesis
J Korean Soc Ultrasound Med
2013 ;32 (2) :132 -142
Yoo Seol Bong, Kim Yu Jung, Kim Hyojin, Jin Yan, Sun Ping-Li, Jheon Sanghoon, Lee Jong Seok, Chung Jin-Haeng
Alteration of the E-cadherin/β-catenin complex predicts poor response to epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI) treatment
ANN SURG ONCOL
2013 ;20 Suppl 3 :S545 -S552
Kim So Young, Kim Jeong-Whun, Park Joo Hyun, Rhee Chae-Seo, Chung Jin-Haeng
Does eosinophilic inflammation affect the outcome of endoscopic sinus surgery in chronic rhinosinusitis in Koreans?
AM J RHINOL ALLERGY
2013 ;27 (6) :e166 -e169
Choi Yong Seok, Park Jin Kyun, Kang Eun Ha, Lee Young-Kyun, Kim Tae Kyun, Chung Jin-Haeng, Zimmerer Jason M, Carson William E, Song Yeong Wook, Lee Yun Jong
Cytokine signaling-1 suppressor is inducible by IL-1beta and inhibits the catabolic effects of IL-1beta in chondrocytes: its implication in the paradoxical joint-protective role of IL-1beta
ARTHRITIS RES THER
2013 ;15 (6)
Lee Sei Won, Lee Choon-Taek, Leem Cho-Sun, Kim Tae Jung, Lee Kyung Won, Jheon Sanghoon, Lee Jae-Ho, Chung Jin-Haeng
The long-term course of ground-glass opacities detected on thin-section computed tomography
RESP MED
2013 ;107 (6) :904 -910
Kim Hyojin, Jang Se Jin, Chung Doo Hyun, Yoo Seol Bong, Sun Pingli, Jin Yan, Nam Kyung Han, Paik Jin-Ho, Chung Jin-Haeng
A comprehensive comparative analysis of the histomorphological features of ALK-rearranged lung adenocarcinoma based on driver oncogene mutations: frequent expression of epithelial-mesenchymal transition markers than other genotype
PLOS ONE
2013 ;8 (10)
Kim Hyojin, Yoo Seol Bong, Sun Pingli, Jin Yan, Jheon Sanghoon, Lee Choon Taek, Chung Jin-Haeng
Alteration of the E-Cadherin/β-Catenin Complex Is an Independent Poor Prognostic Factor in Lung Adenocarcinoma
Korean J Pathol
2013 ;47 (1) :44 -51
Kang Yusuhn, Choi Jung-Ah, Chung Jin-Haeng, Hong Sung Hwan, Kang Heung Sik
Accuracy of preoperative MRI with microscopy coil in evaluation of primary tumor thickness of malignant melanoma of the skin with histopathologic correlation
KOREAN J RADIOL
2013 ;14 (2) :287 -293
Thunnissen Erik, Belien Jeroen A M, Kerr Keith M, Chung Jin-Haeng, Flieder Douglas B, Noguchi Masayuki, Yatabe Yasushi, Hwang David M, Lely Rutger J, Hartemink Koen J, Meijer-Jorna Lorine B, Tsao Ming-Sound
In compressed lung tissue microscopic sections of adenocarcinoma in situ may mimic papillary adenocarcinoma
ARCH PATHOL LAB MED
2013 ;137 (12) :1792 -1797
Lee You-Soub, Bae Suk-Chul, Lee Jung-Won, Jang Ju-Won, Chi Xin-Zi, Kim Jang-Hyun, Li Ying-Hui, Kim Min-Kyu, Kim Da-Mi, Choi Byeung-Sub, Kim Eung-Gook, Lee Ok-Jun, Lee You-Mie, Suh Joo-Won, Chuang Linda Shyue Huey, Ito Yoshiaki, Chung Jin-Haeng
Runx3 inactivation is a crucial early event in the development of lung adenocarcinoma
CANCER CELL
2013 ;24 (5) :603 -616
Chang Youjin, Choi Chang-Min, Kim Seon Ye, Choi Yun Jung, So Kwang Sup, Rho Jin Kyung, Kim Woo Sung, Lee Jae Cheol, Chung Jin-Haeng
Neuroendocrine differentiation in acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitor
Tuberc Respir Dis (Seoul)
2013 ;75 (3) :95 -103
Sun Ping-Li, Jin Yan, Kim Hyojin, Seo An Na, Jheon Sanghoon, Lee Choon-Taek, Chung Jin-Haeng
Survivin expression is an independent poor prognostic marker in lung adenocarcinoma but not in squamous cell carcinoma
VIRCHOWS ARCH
2013 ;463 (3) :427 -436
Sun Ping-Li, Jin Yan, Kim Hyojin, Lee Choon-Taek, Jheon Sanghoon, Chung Jin-Haeng
High concordance of EGFR mutation status between histologic and corresponding cytologic specimens of lung adenocarcinomas
CANCER CYTOPATHOL
2013 ;121 (6) :311 -319
Kim Hyojin, Park Eunhyang, Kim Yu Jung, Chung Jin-Haeng
ALK rearrangement in a pure squamous cell carcinoma: the challenge of detection of ALK rearrangement
VIRCHOWS ARCH
2013 ;462 (5) :597 -599
Shim Hyo Sup, Jang Se Jin, Kim Lucia, Chang Sunhee, Kim Wan-Seop, Lee Geon Kook, Jung Soon-Hee, Chung Jin-Haeng
Guideline Recommendations for EGFR Mutation Testing in Lung Cancer: Proposal of the Korean Cardiopulmonary Pathology Study Group
Korean J Pathol
2013 ;47 (2) :100 -106
Kim Ji Eun, Kim Hyojin, Choe Ji-Young, Sun Pingli, Jheon Sanghoon, Chung Jin-Haeng
High expression of Sonic hedgehog signaling proteins is related to the favorable outcome, EGFR mutation, and lepidic predominant subtype in primary lung adenocarcinoma
ANN SURG ONCOL
2013 ;20 Suppl 3 :S570 -S576
Kim Hyojin, Xu Xianhua, Yoo Seol-Bong, Sun Ping-Li, Jin Yan, Paik Jin Ho, Choe Gheeyoung, Jheon Sanghoon, Lee Choon-Taek, Chung Jin-Haeng
Discordance between anaplastic lymphoma kinase status in primary non-small-cell lung cancers and their corresponding metastases
HISTOPATHOLOGY
2013 ;62 (2) :305 -314
CHUNG JIN HAENG, Ji Young Park, Choon-Taek Lee, Taehoon Lee, Hong Yeul Lee, Hyo-Jeong Lim, Jong Sun Park, Young-Jae Cho, Ho Il Yoon, Jae Ho Lee, Kyung Won Lee, Bo Seong Kim, Kwhanmien Kim
A Case of Lung Squamous Cell Carcinoma Mimicking Benign Solitary Cyst
J Lung Cancer
2012 ;11 (2) :108 -110
Lee Sei Won, Lee Choon-Taek, Kim Dal Rae, Kim Tae Jung, Paik Jin Ho, Jheon Sanghoon, Huh Jin Won, Lee Jae-Ho, Chung Jin-Haeng
The association of down-regulated toll-like receptor 4 expression with airflow limitation and emphysema in smokers
RESP RES
2012 ;13
Jing Jin, Ryu Han Suk, Lee Hyebin, Lee Kyoungbun, Lee Hee Eun, Kim Dae-Ghon, Xu Xianhua, Choe Gheeyoung, Shin Eun, Kim Haeryoung, Jang Ja-June, Chung Jin-Haeng
Overexpression of epithelial-mesenchymal transition-related markers according to cell dedifferentiation: clinical implications as an independent predictor of poor prognosis in cholangiocarcinoma
HUM PATHOL
2012 ;43 (12) :2360 -2370
최영화, 김혜령, 정진행
Liquid-based cytology of villoglandular adenocarcinoma of the cervix: a report of 3 cases
KOREAN J PATHOL
2012
손핑리, 정진행, 김효진
High incidence of EGFR mutations in Korean men smokers with no intratumoral heterogeneity of lung adenocarcinomas: correlation with histologic subtypes, EGFR/TTF-1 expressions, and clinical features
J THORAC ONCOL
2012 ;7 (2) :323 -330
정진행, 이학종, 성일황
Evaluation of Tumor Angiogenesis in a Mouse PC-3 Prostate Cancer Model Using Dynamic Contrast-Enhanced Sonography
J ULTRAS MED
2012 ;31 (8) :1223 -1231
Kim Hye Ryun, Shim Hyo Sup, Chung Jin-Haeng, Lee Young Joo, Hong Yun Kyoung, Rha Sun Young, Kim Se Hoon, Ha Sang-Jun, Kim Se Kyu, Chung Kyung Young, Soo Ross, Kim Joo Hang, Cho Byoung Chul
Distinct clinical features and outcomes in never-smokers with nonsmall cell lung cancer who harbor EGFR or KRAS mutations or ALK rearrangement
CANCER-AM CANCER SOC
2012 ;118 (3) :729 -739
Yi Eunhee S, Chung Jin-Haeng, Kulig Kimary, Kerr Keith M
Detection of anaplastic lymphoma kinase (ALK) gene rearrangement in non-small cell lung cancer and related issues in ALK inhibitor therapy: a literature review
MOL DIAGN THER
2012 ;16 (3) :143 -150
Oh Mee-Hye, Lee Hyun Ju, Yoo Seol Bong, Xu Xianhua, Choi Jae Sung, Kim Yong Hoon, Lee Seok Yeol, Lee Choon-Taek, Jheon Sanghoon, Chung Jin-Haeng
Clinicopathological correlations of mTOR and pAkt expression in non-small cell lung cancer
VIRCHOWS ARCH
2012 ;460 (6) :601 -609
Paik Jin Ho, Choi Chang-Min, Kim Hyojin, Jang Se Jin, Choe Gheeyoung, Kim Dong Kwan, Kim Hwa Jung, Yoon Hoil, Lee Choon-Taek, Jheon Sanghoon, Choe Ji-Young, Chung Jin-Haeng
Clinicopathologic implication of ALK rearrangement in surgically resected lung cancer: a proposal of diagnostic algorithm for ALK-rearranged adenocarcinoma
LUNG CANCER
2012 ;76 (3) :403 -409
Park Jin Hyun, Kim Yu Jung, Lee Jeong-Ok, Lee Keun-Wook, Kim Jee Hyun, Bang Soo-Mee, Chung Jin-Haeng, Kim Jae Sung, Lee Jong Seok
Clinical outcomes of leptomeningeal metastasis in patients with non-small cell lung cancer in the modern chemotherapy era
LUNG CANCER
2012 ;76 (3) :387 -392
정진행, 김여군, 강흥식
Epithelioid Hemangioendothelioma of the Femur with Benign Cystic Appearance.
대한영상의학회지
2011 ;65 (6) :607 -11
정진행, 유인선, 강흥식
Primary Osteoblastic Osteosarcoma of the Rib in an Adult: A Case Report.
대한영상의학회지
2011 ;65 (6) :603 -5
정진행, 유설봉, 백진호
Clinicopathologic Implications of ALK Gene Copy Number Gain in Non-small Cell Lung Cancer
JOURNAL OF LUNG CANCER
2011 ;10 (2) :87 -93
정진행, 이건국, 이종석
Two Consecutive Cases of Platinum-Refractory Pulmonary Pleomorphic Carcinoma that Showed Dramatic Responses to MAID (Mesna, Doxorubicin, Ifosfamide and Dacarbazine) Chemotherapy
JPN J CLIN ONCOL
2011 ;41 (3) :430 -433
정진행, 이근욱, 범승호
Metastatic Adrenocortical Carcinoma Presenting Simultaneously with Cushing's and Conn's Syndromes: A Case Report
JPN J CLIN ONCOL
2011 ;41 (11) :1287 -1291
정진행, 유한석, 허선화
ERCC1 Predicts a Poorer Platinum-based Chemotherapy Outcome but a Better Outcome for Uracil-Tegafur in the Resected Stage I-II NSCLC
KOREAN J PATHOL
2011 ;45 (1) :45 -52
정진행, 전상훈, 백진호
Clinicopathologic implication of ALK rearrangement in surgically resected lung cancer A proposal of diagnostic algorithm for ALK-rearranged adenocarcinoma
LUNG CANCER
2011
정진행, 김혜련, 조병철
Distinct Clinical Features and Outcomes in Never-Smokers With Nonsmall Cell Lung Cancer Who Harbor EGFR or KRAS Mutations or ALK Rearrangement
CANCER-AM CANCER SOC
2011
정진행, 유종진, 이윤종
Risk Factors for the Recurrence of IgG4-Related Sclerosing Disease Without Autoimmune Pancreatitis
JCR-J CLIN RHEUMATOL
2011
정진행, 이세원, 이춘택
EBUS-TBNA in the differential diagnosis of pulmonary artery sarcoma and thromboembolism
EUR RESPIR J
2011
정진행, 최기영, 유설봉
Loss of PTEN Expression is an Independent Poor Prognostic Factor in Non-small Cell Lung Cancer
KOREAN J PATHOL
2011
정진행, 허선화, 이재철
Clinical and molecular evidences of epithelial to mesenchymal transition in acquired resistance to EGFR-TKIs
LUNG CANCER
2011
정진행, 김효진, 유설봉
Detection of ALK Gene Rearrangement in Non-small Cell Lung Cancer
J THORAC ONCOL
2011
정진행, 윤호일, 이지연
Propylthiouracil-Induced Nonspecifi c Interstitial Pneumonia
CHEST
2011
정진행, 전은주, 최정아, 안세진
MR Imaging Findings of a Primary Cardiac Osteosarcoma and Its Bone Metastasis with Histopathologic Correlation
KOREAN J RADIOL
2011 ;12 (1) :135 -139
정진행, 강경훈, 이현주
DNA methylation profile during multistage progression of pulmonary adenocarcinomas
VIRCHOWS ARCH
2011
정진행, 허선화, 손핑리
Aberrant Wnt1/ -Catenin Expression is an Independent Poor Prognostic Marker of Non-small Cell Lung Cancer After Surgery
J THORAC ONCOL
2011
정진행, 백진호, 최기영
Screening of Anaplastic Lymphoma Kinase Rearrangement by Immunohistochemistry in Non-small Cell Lung Cancer Correlation with Fluorescence In Situ Hybridization
J THORAC ONCOL
2011
정진행, 구자원, 조한규
Otologic Manifestation in IgG4-Related Systemic Disease
CLIN EXP OTORHINOLAR
2011
정진행, 이경숙, 배석철
Runx3 is required for the differentiation of lung epithelial cells and suppression of lung cancer
ONCOGENE
2010 :1 -14
정진행, 이윤종, 송영욱, 강은하
Adiponectin is a potential catabolic mediator in osteoarthritis cartilage
ARTHRITIS RES THER
2010 ;12 (6) :r231
정진행
Nested PCR in lung tissue for diagnosis of pulmonary tuberculosis
EUR RESPIR J
2010 ;2010 (35) :851 -857
정진행, 김상은, 이상미
Bone Scintigraphy Findings of A Case with Maffucci’s Syndrome
Nucl Med Mol Imaging
2010 ;44 :150 -153
정진행, 권택균, 김동욱
Laryngeal kaposiform hemangioendothelioma: Case report and literature review
AURIS NASUS LARYNX
2010 ;37 (0) :258 -262
정진행, 오진영, 이춘택
Combination gene therapy of lung cancer with conditionally replicating adenovirus and adenovirus-herpes simplex virus thymidine kinase
INT J MOL MED
2010 ;25 (0) :369 -376
정진행, 이현주
CD24, a Novel Cancer Biomarker, Predicting Disease-Free Survival of Non-small Cell Lung Carcinomas A Retrospective Study of Prognostic Factor Analysis from the Viewpoint of Forthcoming (Seventh) New TNM Classification
J THORAC ONCOL
2010 ;5 (0) :649 -657
정진행, 이현주
Protein overexpression and gene amplification of epidermal growth factor receptor in nonsmall cell lung carcinomas: Comparison of four commercially available antibodies by immunohistochemistry and fluorescence in situ hybridization study
LUNG CANCER
2010 ;68 (0) :375 -382
정진행, 유설봉
Epidermal Growth Factor Receptor Mutation and p53 Overexpression during the Multistage Progression of Small Adenocarcinoma of the Lung
J THORAC ONCOL
2010 ;5 (0) :964 -969
정진행, 유설봉
Reliability of chromogenic in situ hybridization for epidermal growth factor receptor gene copy number detection in non-small-cell lung carciomas:A comparison with fluorescence in situ hybridization study
LUNG CANCER
2010
정진행, 최기영
The accuracy of frozen section diagnosis of pulmonary nodules: evaluation of inflation method during intraoperative pathology consultation with cryosection
J THORAC ONCOL
2010 ;5 (1) :39 -44
정진행, 오주한, 김정임, 최정아, 정진행, 최자영, 강흥식
MR Imaging Features of a Solitary Subcutaneous Metastasis from a Gastric Adenocarcinoma
KOREAN J RADIOL
2009 ;60 (0) :159 -163
정진행, 오주한, 주아진, 최정아, 정진행, 강흥식
Fibroblastic Type Osteosarcoma of the Ulna: a Case Report of a Tumor in a Rare Location with Atypical Imaging Findings.
KOREAN J RADIOL
2009 ;10 (0) :85 -88
정진행, 최기영, 이춘택
Epidermal Growth Factor Receptor Mutation and Pathologic-Radiologic Correlation Between Multiple Lung Nodules with Ground-Glass Opacity Differentiates Multicentric Origin from Intrapulmonary Spread
J THORAC ONCOL
2009
정진행, 이지은, 안순현
Expression of GLUT-1 and EGFR in Head and Neck Squamous Cell Carcinoma
Korean J Otorhinolaryngol-Head Neck Surg
2009
정진행, 백진호, 최기영
Malignant Mesothelioma in Body Fluids - with Special Reference to Differential Diagnosis from Metastatic Adenocarcinoma
KOREAN J PATHOL
2009
정진행, 김형렬, 전상훈
The detection of peripheral lung cancer by MAGE A1-6 RT-nested PCR in bronchial washing specimens
LUNG CANCER
2009
Angioleiomyoma in soft tissue of extremities: MRI findings.
AM J ROENTGENOL
2009
정진행, 최정아, 주이진
Fibroblastic Type Osteosarcoma of the Ulna: a Case Report of a Tumor in a Rare Location with Atypical Imaging Findings
KOREAN J RADIOL
2009
Overexpression of Glut1 in lymphoid follicles correlates with false positive FDG-PET results in lung cancer staging
Journal of Nuclear Medicine
2004 ;45 (6) :999 -1003
A study of moderately differentiated neuroendocrine carcinomas of the larynx and an examination of non-neoplastic larynx tissue for neuroendocrine cells
Laryngoscope
2004 ;114 (7) :1264 -1270
Renal cell carcinoma in South Korea: A multicenter study
Human Pathology
2004 ;35 (12) :1556 -1563
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