From: "Londa Schiebinger" <schieb@stanford.edu>
To: "genderedinnovations@lists.stanford.edu" <genderedinnovations@lists.stanford.edu>;
Cc:
Sent: 2025-05-03 (토) 02:19:11 (UTC+09:00)
Subject: [Gendered Innovations] Som research of interest
Dear Readers, #6 below is a notice of the NIH ORWH Annual Vivian W. Pinn Symposium. I’m glad to see some “business as usual” moving forward. The link is there if you wish to register. Some interesting things here! All best, Londa
1. Navigating the paradigm shift of sex inclusive preclinical research and lessons learnt
NA Karp - Communications Biology, 2025
After thirty years of research highlighting the risk of the sex bias in preclinical
research, we now have tangible change happening in the research landscape with
a rapid increase in the proportions of studies including female and male subjects. In …
K Sjöö - Minerva, 2025
Research funding organizations increasingly steer researchers to integrate certain
perspectives into the content of their research. Little is known, however, about the
mechanisms by which these policies are operationalized. This study addresses a …
2. Important EU publication: Framework for the integration and evaluation of inclusive gender analysis in research and innovation content
Publication metadata
This document was developed by the European Research Area Forum Subgroup on Inclusive Gender Equality in the European Research Area, in close cooperation with the European Commission, with the aim to provide guidance to national authorities and research and innovation
funding organisations on policy measures to ensure the effective implementation and evaluation of the integration of the gender dimension into research and innovation content from an intersectional perspective.
3. RA Moldovan, MR Hidalgo, H Castane, A Jimenez-Franco, J Joven, DJ Burks, A Galan, F Garcia-Garcia. Transcriptomic landscape of sex differences in obesity and type 2 diabetes in subcutaneous adipose tissue. Metabolism. 2025 Mar. doi: 10.1016/j.metabol.2025.156241.
Abstract: Obesity represents a significant risk factor in the development of type 2 diabetes (T2D), a chronic metabolic disorder characterized by elevated blood glucose levels, and a previous step for its development. Significant sex differences have been identified in the prevalence,
development, and pathophysiology of obesity and T2D; however, the underlying molecular mechanisms remain unclear. This study aims to identify sex-specific signatures in obesity and T2D and enhance our understanding of the underlying mechanisms associated with sex differences
by integrating expression data. We performed a systematic review and individual transcriptomic analysis of eight selected studies which included 302 subcutaneous adipose tissue samples. Then, we conducted different gene-level meta-analyses and functional characterizations for
obesity and T2D separately, identifying common and sex-specific transcriptional profiles, many of which were previously associated with obesity or T2D. Overall, our sex-specific meta-analyses supported the detection of differentially expressed genes in males and females associated
with the development of obesity and further T2D development, emphasizing the relevance of sex-based information in biomedical data and opening new avenues for research.
4. C Perpiñá-Clerigues, S Mellado, C Galiana-Rosello, F Garcia-Garcia, M Pascual. Unravelling the impact of TLR4 and sex on chronic alcohol consumption-induced lipidome dysregulation in extracellular vesicles. Journal of Proteome Research 2025 Jan. DOI:
10.1021/acs.jproteome.4c00786. Abstract: The lipids that form extracellular vesicles (EVs) play critical structural and regulatory roles, and cutting-edge bioinformatics strategies have shown the ability to decipher lipid metabolism and related molecular mechanisms. We previously
demonstrated that alcohol abuse induces an inflammatory immune response through Toll-like receptor 4 (TLR4), leading to structural and cognitive dysfunction. This study evaluated how TLR4 and sex as variables (male/female) impact the lipidome of plasma-resident EVs after
chronic alcohol exposure. Using a mouse model of chronic ethanol exposure in wild-type and TLR4-deficient mice, enrichment networks generated by LINEX2 highlighted significant ethanol-induced changes in the EV lipid substrate–product of enzyme reactions associated with
glycerophospholipid metabolism. We also demonstrated ethanol-induced differences in Lipid Ontology enrichment analysis in EVs, focusing on terms related to lipid bilayer properties. A lipid abundance analysis revealed higher amounts of significant lipid subclasses in all
experimental comparisons associated with inflammatory responses and EV biogenesis/secretion. These findings suggest that interrogating EV lipid abundance with a sensitive lipidomic-based strategy can provide deep insight into the molecular mechanisms underlying biological
processes associated with sex, alcohol consumption, and TLR4 immune responses and open new avenues for biomarker identification and therapeutic development.
5. C Perpiñá-Clerigues, S Mellado, C Galiana-Roselló, M Fernández-Regueras, M Marcos, F García-García and M Pascual. Novel insight into the lipid network of plasma extracellular vesicles reveal sex-based differences in the lipidomic profile of alcohol use disorder
patients. Biology of Sex Differences 2024 Jan 25. doi: https://doi.org/10.1186/s13293-024-00584-5. Abstract: Alcohol use disorder (AUD) is one of the most common psychiatric disorders, with the consumption of alcohol considered a leading cause of preventable deaths worldwide.
Lipids play a crucial functional role in cell membranes; however, we know little about the role of lipids in extracellular vesicles (EVs) as regulatory molecules and disease biomarkers. We employed a sensitive lipidomic strategy to characterize lipid species from the plasma EVs of AUD
patients to evaluate functional roles and enzymatic activity networks to improve the knowledge of lipid metabolism after alcohol consumption. We analyzed plasma EV lipids from AUD females and males and healthy individuals to highlight lipids with differential abundance and
biologically interpreted lipidomics data using LINEX2, which evaluates enzymatic dysregulation using an enrichment algorithm. Our results show, for the first time, that AUD females exhibited more significant substrate-product changes in lysophosphatidylcholine/phosphatidylcholine
lipids and phospholipase/acyltransferase activity, which are potentially linked to cancer progression and neuroinflammation. Conversely, AUD males suffer from dysregulated ceramide and sphingomyelin lipids involving sphingomyelinase, sphingomyelin phosphodiesterase, and
sphingomyelin synthase activity, which relates to hepatotoxicity. Notably, the analysis of plasma EVs from AUD females and males demonstrates enrichment of lipid ontology terms associated with “negative intrinsic curvature” and “positive intrinsic curvature”, respectively. Our
methodological developments support an improved understanding of lipid metabolism and regulatory mechanisms, which contribute to the identification of novel lipid targets and the discovery of sex-specific clinical biomarkers in AUD.Any suggestion will be welcome. It would surely
be an excellent opportunity to interact with other researchers.
6. I’m delighted to see this!
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Join us on May 15, 2025, for the 9th Annual Vivian W. Pinn Symposium An NIH Office of Research on Women’s Health annual signature event, the Vivian W. Pinn Symposium, honors the office’s first full-time director, Vivian W. Pinn, M.D. This year’s symposium, “Advancing Data-Driven Innovation for the Health of Women," will be held on May 15, 2025, from 12 p.m. to 4 p.m. EDT. It will focus on how data science skills, resources, and training can build capacity for interdisciplinary data analyses. Don’t miss the capstone address by Raquel Hill, Ph.D., Chair of Computer and Information Sciences and Professor at Spelman College, titled “Advancing Data Innovations for Health Improvements: Possibilities and Pitfalls.” You’ll also hear from a dynamic lineup of speakers throughout the day and during the panel discussion:
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7. Flecha, R., Sáinz Ibañez, M., Sordé Martí, T., Ortega Alonso, D., Trujillo-Barbadillo, G., Dawson, E., & Schiebinger, L., Spanish Foundation for Science and Technology (2022). Towards inclusive science communication: Reflections and successful actions. Spanish Foundation for
Science and Technology. https://doi.org/10.58121/0CE3-4156 This appears in Spanish. You can download the PDF, expert to Word and use Word’s automatic translation function.
8. Towards family-friendly conferences in the geosciences: results from a first survey
E Päffgen, L Schielicke, L Esters - EGUsphere, 2025
In the geoscientific field, building an academic career requires a high level of
dedication to research, frequent publishing, and maintaining visibility within the
academic community. Conferences are the central platforms for networking and …
All best, Londa
Londa Schiebinger
Director, EU/US Gendered Innovations in Science, Health & Medicine, Engineering, and Environment Project
http://genderedinnovations.stanford.edu
John L. Hinds Professor of History of Science, Stanford University
http://www.stanford.edu/dept/HPST/schiebinger.html
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